Elevated serum pesticide levels and risk for Alzheimer disease

A follow up to the study reported in January: http://www.ncbi.nlm.nih.gov/pubmed/24473795


Elevated serum DDE levels are associated with an increased risk for AD and carriers of an APOE4 ε4 allele may be more susceptible to the effects of DDE. Both DDT and DDE increase amyloid precursor protein levels, providing mechanistic plausibility for the association of DDE exposure with AD. Identifying people who have elevated levels of DDE and carry an APOE ε4 allele may lead to early identification of some cases of AD.”

The way I interpret this is that, IF it is residual DDT (DDE) rather than all sorts of pesticides, there is some hope that the current epidemic might calm down, since DDT was banned for most uses, in North America at least. in order to save the birds.

Also of course, although the irony is unbearably tragic, this would mean that younger members of families with cases of dementia are not faced with the same grim odds. I remember well my partner saying “Oh yes, we used to have bed bugs, but then they….went away.”

Hmmm – I know how they went away – DDT!

Saving the birds, saving ourselves?


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2 responses to “Elevated serum pesticide levels and risk for Alzheimer disease

  1. Thank you Rachael Carson