Monthly Archives: January 2014

DDT Breakdown Compound Associated with Alzheimer’s Risk

We know Parkinson’s is associated with 2-4 D, now this very suggestive study indicating that there is an environmental component to Alz.

“…today’s study provides a “wake-up call” to look at environmental factors for Alzheimer’s disease and points researchers toward pesticides as a first area to assess. “We have spent so much time looking for the genetic underpinnings of the disease. Now it’s time to start looking harder at the environment.”

 http://www.businessweek.com/news/2014-01-27/pesticide-ddt-linked-to-heightened-alzheimer-s-risk-study-finds

Bloomberg

27 January 2014

Pesticide DDT Linked to Heightened Alzheimer’s Risk, Study Finds

By Nicole Ostrow

The pesticide DDT, banned in the U.S. because of its toxic effects on wildlife and potential to harm human health, may increase the risk for Alzheimer’s disease, according to the first study linking the chemical to the brain-ravaging illness.

People with Alzheimer’s disease had about four times the level of a DDT byproduct in their blood compared with those who didn’t have the dementia, according to the research published today in the journal JAMA Neurology.

DDT, outlawed in the U.S. in 1972, is still found in blood samples because it can take decades for chemicals to break down. The pesticide is used in other countries, and U.S. residents can ingest it by eating fruits, vegetables and grains that are grown in those areas, researchers said. The study points to the need for more analysis about how environmental factors may interact with genes to boost Alzheimer’s risk, said Jason Richardson, the lead study author.

“We really need more attention on the role of environment and the interaction of your genes and environment for complex diseases such as Alzheimer’s,” Richardson, an associate professor in the Department of Environmental and Occupational Medicine at the Robert Wood Johnson Medical School at Rutgers University in Piscataway, New Jersey, said in a telephone interview. “The prevailing thought has always been it’s a genetic disease. Unfortunately that hasn’t panned out.”

Protein Interactions

Just how DDT and its byproduct, DDE, are linked to Alzheimer’s disease remains unclear. The pesticide may affect levels of proteins in the brain that are associated with the plaque that leads to the disease, Richardson said. More studies are needed to better understand this interaction, he said.

Researchers analyzed blood samples of 86 people who had been diagnosed with Alzheimer’s and 79 patients without the condition. They also analyzed brain samples of 11 Alzheimer’s patients who had died and had previously provided blood samples.

They found DDE in 80 percent of those with Alzheimer’s and 70 percent of those without the disease. Those with Alzheimer’s had DDE levels 3.8 times higher on average. The study also showed that those with the Alzheimer’s gene ApoE4 and high levels of DDE scored the lowest on cognition tests.

“This study demonstrates that there are additional contributors to Alzheimer’s disease that must be examined and that may help identify those at risk of developing Alzheimer’s,” Richardson said in a statement. “It is important because when it comes to diagnosing and treating this and other neurodegenerative diseases, the earlier someone is diagnosed, the more options there may be available.”

No Cure

More than 5 million people in the U.S. have Alzheimer’s, a number projected to triple by 2050, according to the Alzheimer’s Association. There is no treatment for the disease, the most common form of dementia. The only drugs approved for the condition ease symptoms for a few months while the disease continues to worsen.

Steven DeKosky, a professor of neurology at the University of Virginia, wrote in an accompanying editorial that today’s study provides a “wake-up call” to look at environmental factors for Alzheimer’s disease and points researchers toward pesticides as a first area to assess.

“We have spent so much time looking for the genetic underpinnings of the disease. Now it’s time to start looking harder at the environment,” he said in a telephone interview. “We are exploring a lot of ways that the environment may predispose us to or protect us from neurodegenerative diseases later in life. This is a new clue that we will chase down.”

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Unconditional love

At the lunch on Thurs. there were just 4 of us but we had a good chat. All of us feeling a bit overwhelmed.  Thank You for the article about Alzheimer’s it was very excellent. The graphics were really helpful to understand. I wonder if Dementia progresses in a similar way or if tends to be more specific to an area?  Take care my friend. As I looked around the table at lunch, I saw in each of the faces of the ladies there a commitment of love that is a choice, like the Source – God’s Agape love.  I thought when we get “frayed around the edges” It is so important to reconnect to the source to sense His unconditional love for us and wrap ourselves up in it to refresh and equip us for the task.  We can’t run on empty.  I was thinking of putting this on the blog but again forgot how ( in the fray) If you think it is worth it feel free.

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Video on the Alzheimer process

Short and precise – perhaps too precise, or perhaps many people don’t have “normal” Alzheimer’s, — at least in our case the changes tend to be a bit all over the place. For example some of the losses, such as logic, happened much earlier. Nonetheless, this is a good quick intro — perhaps good for family who are resisting information?

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by | January 26, 2014 · 10:40 am

The continual assault

What makes it so difficult, unless you develop the meditative discipline of a saint, (I’m working on it but I’m not there yet!) is the continual assault on your common sense and normal mental processes. I think that is where the fatigue comes from, and also why a break doesn’t really last that long because you get back into good old cheerful caregiving routine, but immediately you are being whacked in the cranium over and over with a rubber carrot….

 

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